In the HBO series, John Adams, there was a brief scene in which we saw the Adams children being treated for smallpox. That scene sparked a bunch of questions from my high school students. The following TED-Ed lesson tackles the topic of smallpox vaccination. Through the lesson students can learn about the history of smallpox, how it spread around the world, and how the smallpox vaccination was developed.
Applications for Education
Besides the historical aspect of this lesson, it could be a good introduction to larger lessons about vaccinations.